Study of mechanical strength and release profile of microneedles made of polymer nanocomposites
Date of Issue2018
School of Chemical and Biomedical Engineering
Microneedles are individual needles or arrays of needles in micro-scale widely used in transdermal drug delivery. They achieve painless administration with delivery of low but sufficient dose of therapeutic agents. Dissolving microneedles, made from biodegradable materials, are able to control drug release by altering their compositions and fabrication processes. This article proposed with new methods to improve the mechanical strength and the drug duration of the biodegradable microneedles based on MeHA. These new methods showed dramatically improvement in mechanical strength for penetration of flat skin model and irregular surface model, which are very promising for drug delivery for skin diseases in further study.