dc.contributor.authorGuo, Siyu
dc.date.accessioned2017-12-11T06:23:21Z
dc.date.available2017-12-11T06:23:21Z
dc.date.issued2017
dc.identifier.citationGuo, S. (2017). Nickel-catalyzed asymmetric transfer hydrogenation. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/72886
dc.description.abstractThis thesis describes my work on nickel-catalyzed asymmetric transfer hydrogenation of unsaturated C=C and C=N bonds using various hydride sources. It contains three main parts. Chapter one reported a highly enantioselective asymmetric hydrogenation of a,b-unsaturated esters with a chiral phosphine ligand, (R)-Me-DuPhos. With formic acid and triethyl amine worked as hydrogen source, excellent conversion and enantioselectivity were obtained. Furthermore, deuterium labeling experiments revealed a possible mechanism. I also reported asymmetric transfer hydrogenation of a,b-unsatureated esters with DMF and water as hydride source. Chapter two described asymmetric transfer hydrogenation of cinnamates, beta- dehydroacetamidoesters and hydrazones with acetic acid and indium powder. With nickel/(S)-Binapine or (R)-Me-DuPhos catalytic system, a series of C=C and C=N gave high enantioselectivities. Chapter three reported asymmetric deuteration of a,b-unsaturated esters with deuterium water and indium powder as hydride source. For all the substrates which we tested, excellent conversion, enantioselectivity and deuterium incorporation were obtained. This work provided a novel methodology for fine chiral deuterated products without expensive and explosive deuterium gas. Removeen_US
dc.format.extent129 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistry::Organometallic compoundsen_US
dc.titleNickel-catalyzed asymmetric transfer hydrogenationen_US
dc.typeThesis
dc.contributor.supervisorZhou Jianrongen_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.degree​Doctor of Philosophy (SPMS)en_US


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