View Item 
      •   Home
      • 1. Schools
      • College of Engineering
      • School of Materials Science and Engineering (MSE)
      • MSE Student Reports (FYP/IA/PA/PI)
      • View Item
      •   Home
      • 1. Schools
      • College of Engineering
      • School of Materials Science and Engineering (MSE)
      • MSE Student Reports (FYP/IA/PA/PI)
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.
      Subject Lookup

      Browse

      All of DR-NTUCommunities & CollectionsTitlesAuthorsBy DateSubjectsThis CollectionTitlesAuthorsBy DateSubjects

      My Account

      Login

      Statistics

      Most Popular ItemsStatistics by CountryMost Popular Authors

      About DR-NTU

      Biodegradable post biopsy breast marker

      Thumbnail
      Teh Wen Hui_Final FYP Report (MSE16-097).pdf (1.420Mb)
      Author
      Teh, Wen Hui
      Date of Issue
      2017
      School
      School of Materials Science and Engineering
      Abstract
      Breast biopsy involves needle extraction of small suspicious lesion breast tissue for diagnosis. A breast marker is inserted subsequently to mark the biopsy site for future targeting and referencing due to the transition of the surrounding tissue after tissue removal and remodeling or healing of tissue around the biopsy site. Currently, metallic markers are available for post breast biopsy and they are stayed permanent should the biopsy test diagnosed as benign. In this study, biodegradable breast marker was proposed as an alternative marker. Prototypes were fabricated with varying composition of Poly (lactic-co-glycolic acid) (PLGA) (in molar ratio 50:50, 75:25 and 82:18) to impart timeframe of degradation in 3, 6 and 9 months and with embedded radiopaque fillers to enhance radiopacity under X-Ray imaging. In vitro degradation of these prototypes was evaluated in term of mass loss and molecular weight. X-ray images on these prototypes throughout the degradation period demonstrated the potential use of formulations for 50:50 and 75:25 up to 1 month while formulation 82:18 had shown consistent visibility up to 9 months. In vivo feasibility study was performed on rabbit breast model, demonstrated good visibility in the initial stage of deployment.  
      Subject
      DRNTU::Engineering::Materials
      Type
      Final Year Project (FYP)
      Rights
      Nanyang Technological University
      Collections
      • MSE Student Reports (FYP/IA/PA/PI)

      Show full item record


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       


      NTU Library, Nanyang Avenue, Singapore 639798 © 2011 Nanyang Technological University. All rights reserved.
      DSpace software copyright © 2002-2015  DuraSpace
      Contact Us | Send Feedback
      Share |    
      Theme by 
      Atmire NV
       

       

      DCSIMG