dc.contributor.authorLee, Angeline Jia Hui
dc.date.accessioned2016-05-25T07:07:37Z
dc.date.available2016-05-25T07:07:37Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10356/68347
dc.description.abstractGraphene quantum dot (GQD) is a nanoscale fluorescent particle which has various applications. It is synthesized from a suitable carbon precursor by either a top- down or a bottom- up approach like microwave- assisted, solvothermal, cage opening and other exfoliation reactions. For this project, GQDs were used and studied for as a drug carrier. The target cells are HeLa, which are cervical cancer cells. The optimal condition for the drug loading onto the GQDs occurred at pH 8 while drug release was triggered rapidly at pH 5.5 (tumor pH). This experimental result provides an indication that the loading and release of beta- Lapachone can be controlled by changes in the pH of the solution. This characteristic proves to be a great advantage as tumor cells are slightly acidic in nature. The biocompatibility assay ensured the non-cell toxic nature of GQDs. Based on the cell viability (MTT) test, the results showed that in the presence of free drug and beta- lapachone- loaded GQD there was a significant reduction in cancer cell viability. This study would thus prove the efficacy of GQDs as drug carriers to cancerous cells.en_US
dc.format.extent42 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Engineeringen_US
dc.titleGraphene quantum dot as drug carriersen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorChen Pengen_US
dc.contributor.schoolSchool of Chemical and Biomedical Engineeringen_US
dc.description.degreeBachelor of Engineering (Chemical and Biomolecular Engineering)en_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record