dc.contributor.authorChew, Clement Kai Hong
dc.date.accessioned2016-05-25T03:57:17Z
dc.date.available2016-05-25T03:57:17Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/10356/68248
dc.description.abstractIn colorectal cancer (CRC), plasma levels of LRG1 is observed to be increased in female patients before their diagnosis of CRC. In addition, LRG1 is reported to positively correlate colonic adenoma in a rodent model of CRC. More recently, LRG1 was reported to be able to modulate epithelial-mesenchymal transition of some CRC cell lines. Attempts to elucidate how LRG1 modulates TGF-β signalling, proliferation rate and cell cycle in HCT-15 and HT-29 CRC cell lines were made via western blot, LRG1 overexpression and MTS proliferation assays. Preliminary data hints that LRG1 upregulates TGF-β signaling molecules promote proliferation of HCT-15 and HT-29 CRC cells lines. This presents LRG1 a potential cancer drug target in the context of CRC.en_US
dc.format.extent39 p.en_US
dc.language.isoenen_US
dc.rightsNanyang Technological University
dc.subjectDRNTU::Scienceen_US
dc.titleThe role of leucine-rich alpha-2-glycoprotein 1 (LRG1) in colorectal cancer cellsen_US
dc.typeFinal Year Project (FYP)en_US
dc.contributor.supervisorWang Xiaomengen_US
dc.contributor.schoolCollege of Scienceen_US
dc.description.degreeBachelor of Science in Biological Sciencesen_US


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