Ooi, Chui Ping
Date of Issue2004
School of Materials Engineering
This report consists of 3 projects: Project 1: Nano and microparticles for drug delivery Part 1 - At present stage, we have developed a PLGA microparticle system which has a particle size range of 3-8 micron. It has the particle size especially suitable for intravenous administration. which is desired to prevent capillary clogging and phagocytosis. Part 2 - In this project, poly (lactic-co-glycolic acid 75:25, PLGA), IV 0.94 dl/g, was chosen as the matrix of the microparticles. Bovine serum albumin (BSA) (Fraction V) as the model drug was incorporated in the microparticles by a w/o/w emulsification and solvent evaporation technique. The relationships between the various preparation parameters and the size, morphology and drug loading efficiency and drug release profiles of the resultant microparticles were examined. Project 2: Plasma Spray processing of functionally graded bioceramic nano-composites The project was to find a bioceramic based composite with suitable mechanical properties and biological properties so that the composite material would be used to manufacture load-bearing implants for bone replacement applications. Project 3: In-vitro and in-vivo evaluation of biomaterials The project was designed to evaluate the biocompatibility, osteointegration and osteoinduction of biomaterials in vivo and in vitro.
Nanyang Technological University