Synthesis of high value chemicals from biomass platform chemicals
Koh, Jackson Peng Fei
Date of Issue2016-05-11
School of Physical and Mathematical Sciences
In this thesis, the conversion of biomass to several high value chemicals via versatile and synthetically useful platform chemicals was described. These high value chemicals include a common intermediate that allow access to several potent NK1 receptor antagonists which are associated with the treatment of anxiety and emesis, as well as biologically active natural products aspergillides A and B with cytotoxic activity against mouse lymphocytic leukemia cell (L1210). In particular, the syntheses of aspergillides A and B was achieved such that all of the carbons present are derived from biomass derived platform chemicals. These demonstrate the feasibility of constructing valuable biologically active compounds using a sustainable chemical feedstock like biomass.
DRNTU::Science::Chemistry::Organic chemistry::Organic synthesis