Preparation of chiral EC(sp3)E’ phosphine-based mono- and di-nuclear palladium pincer complexes
Tay, Wee Shan
Date of Issue2016
School of Physical and Mathematical Sciences
Ten enantiopure Pd pincer complexes with aliphatic and unsymmetrical characteristics have been synthesized efficiently. Chirality on the ligand backbone was introduced via an asymmetric H-P bond addition reaction by two structurally-dissimilar catalysts with >99% ee’s. Challenging C(sp3)-H bond activation during palladation proceeded with high yields and excellent diastereoselectivities under optimized conditions. Several crystal structures were isolated and discussed. Selected pincer complexes were also employed in a chirality “self-breeding” protocol, in which infinite replicates of a catalyst may be synthesized by itself. Excellent results were obtained, with the selected complex being capable of producing itself with the exact absolute stereoconfiguration with >99% ee at RT.
DRNTU::Science::Chemistry::Organic chemistry::Organometallic compounds