Development of novel interrupted nazarov cyclizations for construction of diverse cyclopentanoid compunds
Date of Issue2016
School of Physical and Mathematical Sciences
The prevalence of five-membered carbocyclic framework in natural products and biologically relevant compounds has propelled the development of Nazarov cyclization into a reliable synthetic method for construction of cyclopentanoid compounds. Some of the critical advances with regard to control of regioselectivity in the elimination step, understanding substituent effects on reactivity, the use of alternative substrate as precursor to pentadienyl cation and the development of asymmetric reaction, which have greatly increased the synthetic utility of Nazarov cyclization will be discussed in Chapter 1.