The biosynthesis of vitamin E in the bacteria Escherichia coli
Lieviant, Jane Andrea
Date of Issue2014
The lipid antioxidant vitamin E is among the supplements essential for humans and animals. Its biosynthesis pathways in plants and cyanobacteria have been elucidated and studied, cloned and expressed in order to enhance the vitamin E contents of producer crops. For decades, Escherichia coli has been the primary workhorse for recombinant pharmaceuticals, especially for small molecules and proteins not requiring complex posttranslational modifications. This work reviews the biosynthesis of tocochromanols, their functions, and past efforts in engineering the pathway, and the possibilities for E. coli as the optimal host system.