dc.contributor.authorAlexis, Franken_US
dc.date.accessioned2008-09-17T10:18:24Z
dc.date.available2008-09-17T10:18:24Z
dc.date.copyright2005en_US
dc.date.issued2005
dc.identifier.citationAlexis, F. (2005). Drug release mechanisms from bioerodible polymers for stent application. Doctoral thesis, Nanyang Technological University, Singapore.
dc.identifier.urihttp://hdl.handle.net/10356/5048
dc.description.abstractThe effect of the chemical nature of the drug on matrix degradation and drug release behavior of degradable polymers was studied, using lidocaine as a model drug in base and salt forms. As matrices, a range of lactide/glycolide based polymers was studied, representing variation in composition, crystallinity and molecular weight. We showed in this study that the drug in the base form has a substantial effect on the release characteristics, through an accelerating effect on matrix degradation. Study of drug release from PdlLGA showed that lidocaine salt followed a triphasic release pattern, in contrast to the biphasic release of the lidocaine.en_US
dc.format.extent245 p.
dc.rightsNanyang Technological Universityen_US
dc.subjectDRNTU::Engineering::Materials::Biomaterials
dc.titleDrug release mechanisms from bioerodible polymers for stent applicationen_US
dc.typeThesisen_US
dc.contributor.supervisorVenkatraman, Subbuen_US
dc.contributor.schoolSchool of Materials Science and Engineeringen_US
dc.description.degreeDoctor of Philosophy (SME)en_US
dc.contributor.supervisor2Boey, Freddy Yin Chiangen_US


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