dc.contributor.authorTan, Hong Yee.
dc.date.accessioned2012-05-21T04:12:32Z
dc.date.available2012-05-21T04:12:32Z
dc.date.copyright2012en_US
dc.date.issued2012
dc.identifier.urihttp://hdl.handle.net/10356/49504
dc.description.abstractIn part A, we have established an efficient iron-catalyzed decarboxylative C-glycosylation of glycals with β-keto acids via decarboxylative Ferrier rearrangement strategy. This approach provides a wide range of β-keto-functionalized 2,3-unsaturated C-glycosides in moderate to good yields. Good α-selectivities are mainly observed with the use of D-galactals along with the bulkier β-keto acids bearing phenyl moieties. In part B, we have developed a highly regio- and stereoselective formation of β-O-arylpseudoglucals via palladium-catalyzed decarboxylative O-glycosylation strategy. This approach essentially relies on palladium’s decarboxylative feature to eliminate the carboxylate group located in C3 position, subsequently liberating phenolic nucleophile to attack onto the electron deficient anomeric position. This reaction system successfully provides a facile and direct entry to exclusive selectivity for β-O- glycosides.en_US
dc.format.extent70 p.en_US
dc.language.isoenen_US
dc.subjectDRNTU::Science::Chemistry::Organic chemistry::Carbohydratesen_US
dc.titleNew strategies for O- and C-glycosylation.en_US
dc.typeThesis
dc.contributor.supervisorLiu Xuewei (SPMS)en_US
dc.contributor.schoolSchool of Physical and Mathematical Sciencesen_US
dc.description.degreeMSC(SPMS)en_US


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