Large hollow nanoparticle aggregates as aerosol carrier particles of nanoparticulate drug for dry powder inhaler (DPI) applications : strength of aggregates and particle deposition pattern.
Kunn, Hadinoto Ong.
Date of Issue2010
School of Chemical and Biomedical Engineering
The emerging trend in the drug discovery process towards identification of poorly-soluble compounds as the lead drug candidates is a consequence of the inherent bias in the high-throughput drug screening method towards lipophilic molecules. Over 40% of the newly discovered drug molecules that are currently in the pharmaceutical pipeline exhibit a poor aqueous solubility that limits their therapeutic efficacy. In addition, approximately 17% of the drug products that are available in the market exhibit a low bioavailability as a result of the poor solubility of their solid dosage form formulation necessitating the use of high and frequent dosings. The systemic bioavailability of poorly-soluble compounds can be greatly enhanced by encapsulating the drug molecules into biocompatible nanoparticulate carriers as a result of the higher dissolution rate.
DRNTU::Engineering::Chemical engineering::Chemical processes